You can combine 5 to 7 single remedies and up to 3 mixed remedies at a time. Each bottle has about 90 drops. It can be put in the mouth, on the nose, in water, rubbed into inner part of ear flap that has no fur, put into a sprayer and spray around the animal, or put in food. If dropper touches the mouth or saliva, rinse dropper off before putting it back in the bottle. Dose lasts 5-7 hours. Can give 3 to 4 times a day, mroe often if needed. Less that 10 lbs use 2 drops, 10-80lb use 4 drops, 80+lb use drops. In water bowl us 6-10 drops, depending on size of bowl.